A two-storage model for deteriorating items with holding cost under inflation and Genetic Algorithms

A deterministic inventory model has been developed for deteriorating items and Genetic Algorithms (GA) having a ramp type demands with the effects of inflation with two-storage facilities. The owned warehouse (OW) has a fixed capacity of W units; the rented warehouse (RW) has unlimited capacity. Here, we assumed that the inventory holding cost in RW is higher than those in OW. Shortages in inventory are allowed and partially backlogged and Genetic Algorithms (GA) it is assumed that the inventory deteriorates over time at a variable deterioration rate. The effect of inflation has also been considered for various costs associated with the inventory system and Genetic Algorithms (GA). Numerical example is also used to study the behaviour of the model. Cost minimization technique is used to get the expressions for total cost and other parameters

A Two-Warehouse Model for Deteriorating Items with Holding Cost under Particle Swarm Optimization

A deterministic inventory model has been developed for deteriorating items and Particle Swarm Optimization (PSO) having a ramp type demands with the effects of inflation with two-warehouse facilities. The owned warehouse (OW) has a fixed capacity of W units; the rented warehouse (RW) has unlimited capacity. Here, we assumed that the inventory holding cost in RW is higher than those in OW. Shortages in inventory are allowed and partially backlogged and Particle Swarm Optimization (PSO) it is assumed that the inventory deteriorates over time at a variable deterioration rate. The effect of inflation has also been considered for various costs associated with the inventory system and Particle Swarm Optimization (PSO). Numerical example is also used to study the behaviour of the model. Cost minimization technique is used to get the expressions for total cost and other parameters

Prevalence and Genotypes of Mycobacterium Avium Subspecies Paratuberculosis in Large Ruminants of Eastern Uttar Pradesh, North India

Uttar Pradesh is the fourth largest, most populous and leading milk and meat producing state in India. Despite the huge livestock population, information on the status of paratuberculosis homogeneity and heterogeneity of Mycobacterium avium subspecies paratuberculosis (MAP) isolates of eastern Uttar Pradesh is non-existent. Present study was aimed to estimate the presence of MAP in large ruminants (Cattle and Buffaloes) of eastern Uttar Pradesh. A total 108 fecal samples were collected from farmer's herds of large ruminants (cattle and buffaloes) from different geographical regions (Chandauli, Mughalsarai, Gazipur, and Naugarh) of eastern Uttar Pradesh and screened for the presence of MAP infection using microscopic examination, direct IS900 PCR and culture on Herrold egg yolk (HEY) medium. The isolates recovered on HEY medium were subjected to molecular identification and genotyping using IS900 PCR and IS1311 PCR-REA method, respectively. Of the 108 fecal samples, 25 (23.14%) and 11 (10.18%) samples were positive for the presence of acid-fast bacilli and growth on HEY medium, respectively. Species-wise, 17.5, 7.5% and 26.5, 11.7% fecal samples from cattle and buffaloes were found positive for the presence of acid-fast bacilli and growth on HEY medium, respectively. Isolates recovered on HEY medium with mycobactin J were positive for IS900 sequence and genotyped as Bison Type using IS1311 PCR-REA method. Present study is the first report on the presence of MAP infection and ‘Bison Type' genotype of MAP in eastern Uttar Pradesh. These findings will be useful for the intervention of effective control measures in order to reduce the prevalence of MAP infection in domestic livestock species and prevent its spread to the human population in the regions

Study of the immediate short term clinical and radiological outcome of intertrochanteric neck of femur fractures treated with primary bipolar hemiarthroplasty in geriatric population in a tertiary care centre

Background: Intertrochanteric fracture in elderly patient is a frequent problem and is becoming more common as the proportion of elderly people in the population increases. Unstable intertrochanteric fracture in the elderly patient is associated with a high rate of mortality as much as 20 percent during the first postoperative year. The treatment of such unstable intertrochanteric fracture is still controversial. So as to allow for earlier postoperative weight-bearing, primary hemiarthroplasty was proposed by some authors. The purpose of this study is to evaluate the functional and clinical outcomes of cemented bipolar arthroplasty as a primary treatment for unstable intertrochanteric fracture in the elderly patient.Methods: It was an observational retrospective plus prospective study design over a period of 18 months in a tertiary care setting with a sample size of 41. Patients fulfilling the inclusion criteria were assessed clinically using Harris hip score and radiologically were operated for bipolar hemiarthroplasty. They were assessed intraoperatively, immediate postoperatively and after 4 weeks for functional outcome using Harris hip score and assessed radiologically. Patients were also be evaluated for intraoperative and postoperative complications if any. The outcome was analysed statistically to comment on functional outcome of bipolar hemiarthroplasty.Results: In our study majority of the patients 70% (29) had excellent and good outcomes at the end of 1 month. Out of the rest 22% more had fair outcome at the end of month. Thus 93% patients had favorable outcomes at the end of 1 month while 7% (3 cases) had poor outcome when measured using Harris hip score.Conclusions: Primary cemented bipolar hemiarthroplasty is a viable option that leads to good functional outcomes and allows early mobilization and weight bearing

Magnetization hysteresis and time decay measurements in FeSe0.50_{0.50}Te0.50_{0.50} : Evidence for fluctuation in mean free path induced pinning

We present results of magnetic measurements relating to vortex phase diagram in a single crystal of FeSe$_{0.5}$Te$_{0.5}$ which displays second magnetization peak anomaly for $H \parallel c$. The possible role of the crystalline anisotropy on vortex pinning is explored via magnetic torque magnetometry. We present evidence in favor of pinning related to spatial variations of the charge carrier mean free path leading to small bundle vortex pinning by randomly distributed (weak) pinning centers for both $H \parallel c$ and $H \perp c$. This is further corroborated using magnetization data for $H \parallel c$ in a single crystal of FeSe$_{0.35}$Te$_{0.65}$. Dynamical response across second magnetization peak (SMP) anomaly in FeSe$_{0.5}$Te$_{0.5}$ has been compared with that across the well researched phenomenon of peak effect (PE) in a single crystal of CeRu$_2$.Comment: 11 figures, provided additional data in another sample, added Fig.

Bulk Viscous LRS Biachi-I Universe with variable GG and decaying Λ\Lambda

The present study deals with spatially homogeneous and totally anisotropic locally rotationally symmetric (LRS) Bianchi type I cosmological model with variable $G$ and $\Lambda$ in presence of imperfect fluid. To get the deterministic model of Universe, we assume that the expansion $(\theta)$ in the model is proportional to shear $(\sigma)$. This condition leads to $A=\ell B^{n}$, where $A$,\;$B$ are metric potential. The cosmological constant $\Lambda$ is found to be decreasing function of time and it approaches a small positive value at late time which is supported by recent Supernovae Ia (SN Ia) observations. Also it is evident that the distance modulus curve of derived model matches with observations perfectly.Comment: 11 pages, 4 figures and 1 table, Accepted for publication in Astrophysics and Space Scienc

Polymer coated cerium oxide nanoparticles as oxidoreductase-like catalysts

Cerium oxide nanoparticles have been shown to mimic oxidoreductase enzymes by catalyzing the decomposition of organic substrates and reactive oxygen species. This mimicry can be found in superoxide radicals and hydrogen peroxides, harmful molecules produced in oxidative stress asso-ciated diseases. Despite the fact that nanoparticle functionalization is mandatory in the context of nanomedicine, the influence of polymer coatings on their enzyme-like catalytic activity is poorly understood. In this work, six polymer coated cerium oxide nanoparticles are prepared by associa-tion of 7.8 nm cerium oxide cores with two poly(sodium acrylate) and four poly(ethylene glycol) (PEG) grafted copolymers with different terminal or anchoring end groups, such as phosphonic acids. The superoxide dismutase-, catalase-, peroxidase- and oxidase-like catalytic activities of the coated nanoparticles were systematically studied. It is shown that the polymer coatings do not af-fect the superoxide dismutase-like, impair the catalase-like and oxidase-like and surprisingly im-proves peroxidase-like catalytic activities of cerium oxide nanoparticles. It is also demonstrated that the particles coated with the PEG-grafted copolymers perform better than the poly(acrylic acid) coated ones as oxidoreductase-like enzymes, a result that confirms the benefit of having phosphon-ic acids as anchoring groups at the particle surface.Comment: 23 pages, 8 figures, 3 table